Clinical Perspective

The sandwich sign

Nasreen Mahomed, Halvani Moodley
South African Journal of Radiology | Vol 16, No 3 | a295 | DOI: | © 2012 Nasreen Mahomed, Halvani Moodley | This work is licensed under CC Attribution 4.0
Submitted: 24 February 2012 | Published: 10 September 2012

About the author(s)

Nasreen Mahomed, university of witwatersrand, South Africa
Halvani Moodley, university of witwatersrand, South Africa


The sandwich sign refers to the sandwiching of mesenteric vessels and fat by enlarged mesenteric nodes on cross-sectional imaging, commonly occurring in lymphoma, but not specific to lymphoma. The sign is radiologically indistinguishable from post-transplant lymphoproliferative disorders. The radiological significance of the sandwich sign is in suggesting the diagnosis of lymphoma so that appropriate treatment may be initiated early as the tumour has a rapid growth pattern.


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