Review Article

The role of imaging in rheumatoid arthritis

Kgomotso Kgoebane, Mahmood M.T.M. Ally, Martha C. Duim-Beytell, Farhana E. Suleman
South African Journal of Radiology | Vol 22, No 1 | a1316 | DOI: https://doi.org/10.4102/sajr.v22i1.1316 | © 2018 Kgomotso Kgoebane, Mahmood MTM Ally, Martha C. Duim-Beytell, Farhana E. Suleman | This work is licensed under CC Attribution 4.0
Submitted: 07 February 2018 | Published: 11 July 2018

About the author(s)

Kgomotso Kgoebane, Department of Radiology, University of Pretoria, South Africa
Mahmood M.T.M. Ally, Department of Internal Medicine, University of Pretoria, South Africa
Martha C. Duim-Beytell, Department of Internal Medicine, University of Pretoria, South Africa
Farhana E. Suleman, Department of Radiology, University of Pretoria, South Africa

Abstract

Conventional radiographs of the hands and feet have traditionally been used in the diagnosis, management and monitoring of patients with rheumatoid arthritis (RA). However, they are not sensitive enough to detect changes early in the disease process. Erosions may only be visible up to two years after the onset of disease, and soft tissue involvement may not be detected at all. Early diagnosis can also be made challenging as markers such as erythrocyte sedimentation rate and C-reactive protein may be normal in up to 20% – 25% of cases. The latest classification criteria (American College of Rheumatology/European League Against Rheumatism [ACR/EULAR] Rheumatoid Arthritis Classification criteria 2010), often used to diagnose RA, incorporate the role of ultrasound and magnetic resonance imaging detection of synovitis, enabling earlier diagnosis and correct classification of patients. This article looks at the role of the various imaging modalities used in the diagnosis and management of RA.


Keywords

rheumatoid arthritis; ultrasound; MRI; bone marrow oedema; synovitis; erosions

Metrics

Total abstract views: 5825
Total article views: 9064

 

Crossref Citations

1. Limited discriminatory value of RAMRIS findings between RA and hand osteoarthritis: a cross-sectional MRI study
Philipp Sewerin, David Kiefer, Jean Maurice Arcq, Styliani Tsiami, Johanna Mucke, Anna Kernder, Uta Kiltz, Xenofon Baraliakos
Rheumatology International  vol: 46  issue: 3  year: 2026  
doi: 10.1007/s00296-026-06085-5

2. Rheumatologische Nebenwirkungen von Checkpointinhibitoren und deren Behandlung
Lea Grümme, Hendrik Schulze-Koops
Zeitschrift für Rheumatologie  vol: 82  issue: 3  first page: 187  year: 2023  
doi: 10.1007/s00393-022-01311-4

3. Harmonizing Medicine and Surgery in the Pursuit of Boolean Remission: A Rheumatological Magnum Opus
Abdur Rehman , Jinal Choudhari, Abdullah Shehryar, Maryam Affaf, Hareem Ata, Wajiha Batool, Bilal Khan, Iti Mehra, Rayan W Gasim, Quratulain Fatima Masood, Nabila N Anika, Shehryar Rehman
Cureus  year: 2023  
doi: 10.7759/cureus.48205

4. Advancing Personalized Care in Rheumatoid Arthritis: A Novel Framework Using NNT, ARR, and Quality of Life Metrics
Daniela Matei, Anca Maria Amzolini, Miruna Andreiana Matei, Anda Pătru, Mihai Cealîcu, Maria Teodora Amzolini, Magdalena Rodica Trăistaru, Ana Maria Bumbea, Constantin Munteanu, Simona Pătru
Balneo and PRM Research Journal  vol: 16  issue: Vol 16 No. 1  first page: 789  year: 2025  
doi: 10.12680/balneo.2025.789

5. Imaging Immune Cells Using Fc Domain Probes in Mouse Cancer Xenograft Models
Wendy Bernhard, Kris Barreto, Ayman El-Sayed, John DeCoteau, C. Ronald Geyer
Cancers  vol: 14  issue: 2  first page: 300  year: 2022  
doi: 10.3390/cancers14020300

6. Head-to-head comparison of ultrasound and 99mTc-glucosamine SPECT/CT imaging of patients with rheumatoid arthritis: a single center prospective study
Osayande Evbuomwan, Gerrit Engelbrecht, Cathryn Driver, Joseph Sempa, Barend Jansen van Rensburg, Mathys Labuschagne, Je’nine Horn-Lodewyk
Egyptian Journal of Radiology and Nuclear Medicine  vol: 54  issue: 1  year: 2023  
doi: 10.1186/s43055-023-01168-w

7. Advanced application of metal nanoparticles in the diagnosis and treatment of rheumatoid arthritis
Wenjing Zhang, Tingting Xu, Yu Chen, Guiyang Zhang, Yongbo Song
Polyoxometalates  vol: 4  issue: 1  first page: 9140082  year: 2025  
doi: 10.26599/POM.2024.9140082

8. Monitoring of rheumatoid arthritis: a patient survey on disease insight and possible added value of an innovative inflammation monitoring device
Ria Wolkorte, Lieke Heesink, Michelle M. A. Kip, Hendrik Koffijberg, Monique Tabak, Christiane Grünloh
Rheumatology International  vol: 42  issue: 9  first page: 1565  year: 2022  
doi: 10.1007/s00296-021-05026-8

9. A Stepwise Approach to Analyzing Musculoskeletal Imaging Data With Artificial Intelligence
John P. Mickley, Austin F. Grove, Pouria Rouzrokh, Linjun Yang, A. Noelle Larson, Joaquin Sanchez‐Sotello, Hilal Maradit Kremers, Cody C. Wyles
Arthritis Care & Research  vol: 76  issue: 5  first page: 590  year: 2024  
doi: 10.1002/acr.25260

10. Comprehensive Review Of Rheumatoid Arthritis: Insights, Challenges, And Prospects
Mamta Kumari, Piyushkumar Sadhu, Niyati Shah, Chitrali Talele, Dipti Gohil
Journal of Advanced Zoology  vol: 45  issue: 1  year: 2024  
doi: 10.17762/jaz.v45iS1.2892

11. Checkpoint-Inhibitoren in der Onkologie: Rheumatologische Symptome beherrschen
Lea Grümme, Hendrik Schulze-Koops
Deutsches Ärzteblatt Online  year: 2022  
doi: 10.3238/PersOnko.2022.02.18.03

12. Checkpoint-Inhibitoren beim malignen Melanom: Rheumatologische Symptome beherrschen
Lea Grümme, Hendrik Schulze-Koops
Deutsches Ärzteblatt Online  year: 2022  
doi: 10.3238/PersOnko.2022.03.04.02

13. Synthetic Inflammation Imaging with PatchGAN Deep Learning Networks
Aniket A. Tolpadi, Johanna Luitjens, Felix G. Gassert, Xiaojuan Li, Thomas M. Link, Sharmila Majumdar, Valentina Pedoia
Bioengineering  vol: 10  issue: 5  first page: 516  year: 2023  
doi: 10.3390/bioengineering10050516

14. Nano-based Therapeutics for Rheumatoid Arthritis: Recent Patents and Development
Manish Makhija, Deeksha Manchanda, Manu Sharma
Recent Patents on Nanotechnology  vol: 19  issue: 1  first page: 56  year: 2025  
doi: 10.2174/1872210518666230905155459