Original Research

The role of MRI with diffusion-weighted imaging in restaging rectal cancers after neoadjuvant chemoradiotherapy

Irem Bayram, Baris Bakir, Merve G.D. Kartal, Enver Kunduz, Onur Bayram, Rustu Turkay, Oktar Asoglu, Yersu Kapran
South African Journal of Radiology | Vol 20, No 1 | a967 | DOI: https://doi.org/10.4102/sajr.v20i1.967 | © 2016 Irem Bayram, Baris Bakir, Merve G.D. Kartal, Enver Kunduz, Onur Bayram, Rustu Turkay, Oktar Asoglu, Yersu Kapran | This work is licensed under CC Attribution 4.0
Submitted: 08 December 2015 | Published: 21 September 2016

About the author(s)

Irem Bayram, School of Medicine, Istanbul University, Turkey
Baris Bakir, School of Medicine, Istanbul University, Turkey
Merve G.D. Kartal, School of Medicine, Istanbul University, Turkey
Enver Kunduz, Department of General Surgery, Bezmi Alem Vakıf University, Turkey
Onur Bayram, School of Medicine, Koc University, Turkey
Rustu Turkay, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey
Oktar Asoglu, Liv Hospital, Istanbul, Turkey
Yersu Kapran, American Hospital, Istanbul, Turkey


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Abstract

Background: It is challenging to restage rectal cancer at MRI, in patients who have had neoadjuvant chemoradiotherapy.

Objective: To investigate the accuracy of MRI with diffusion-weighted imaging (DWI) in the restaging of rectal cancer.

Materials and methods: Pre- and post-neoadjuvant chemoradiotherapy MRI examinations of 35 patients diagnosed with locally advanced rectal cancer were evaluated and subsequently compared with post-operative pathology results.

Results: The accuracy of MRI with DWI to determine the T-stage status was calculated as 54.28%. Kappa statistics revealed poor concordance with pathology results, with a κ value of 0.212 ± 0.114 (p = 0.028). The apparent diffusion coefficient (ADC) values measured after the neoadjuvant chemotherapy revealed a significant increase when compared with pre-treatment ADC values (p < 0.000001). MRI accuracy rate for lymph node involvement was calculated as 57.14% with a κ value of 0.001 (p = 0.989). MRI had 80% sensitivity and 100% specificity in determining mesorectal fascia involvement, with a calculated positive predictive value of 100% and a calculated negative predictive value of 96%. The accuracy of MRI in overall staging according to the TNM staging system was 28%.

Conclusion: The accuracy of MRI in restaging rectal cancer is not yet sufficient and is not on par with the accuracy of MRI in the primary staging of the disease. This is attributed to post-treatment changes. Adding DWI to the protocol is promising, but more expanded data are required.


Keywords

MRI, rectal cancer, restaging, neoadjuvant therapy, diffusion weighted MRI

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Crossref Citations

1. Locally advanced rectal cancer: qualitative and quantitative evaluation of diffusion-weighted magnetic resonance imaging in restaging after neoadjuvant chemo-radiotherapy
Maria Napoletano, Daniele Mazzucca, Enrico Prosperi, Maria Cristina Aisa, Marco Lupattelli, Cynthia Aristei, Michele Scialpi
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doi: 10.1007/s00261-019-02012-4