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Original Research
The impact of optic nerve movement on optic nerve magnetic resonance diffusion parameters
Submitted: 05 March 2014 | Published: 15 December 2014
About the author(s)
Anand Moodley, Department of Neurology, Grey’s Hospital, University of KwaZulu-Natal, South AfricaWilliam I.D. Rae, Department of Medical Physics, University of the Free State, South Africa
Yarish Brijmohan, Department of Electrical, Electronic and Computer Engineering, University of KwaZulu-Natal, South Africa
Miranda Durand, Department of Radiology, Grey’s Hospital, South Africa
Catherine Connolly, Biostatistics Unit, Medical Research Council, South Africa
Andrew Michowicz, Department of Medicine, Edendale Hospital, South Africa
Ahmed Bhigjee, Department of Neurology, University of KwaZulu-Natal, South Africa
Abstract
Method: Twenty-nine healthy volunteers with intact vision and intact conjugate gaze were recruited and subjected to magnetic resonance diffusion-weighted imaging (DWI) and diffusion-tensor imaging (DTI) of the optic nerves. Twenty right eyes had nerve tracking done using single-shot echo-planar imaging at 20 time points over 3 minutes. Optic nerve movement measurements were correlated with diffusion parameters of apparent diffusion coefficient (ADC), mean diffusivity (MD), fractional anisotropy (FA) and anisotropic index(AI) using Spearman’s rank correlation.
Results: No significant correlations were noted between optic nerve movement parameters and ADC in the axial plane and MD of the optic nerve. Low to moderate negative correlations were noted between optic nerve movement parameters and AI and FA and positive correlation with ADC in the radial plane.
Conclusion: Optic nerve movement documented during the timespan of standard diffusion sequences (DWI and DTI) has a negative effect on the anisotropic diffusion parameters of the optic nerve. With greater eye movement, optic nerve diffusion appears less anisotropic owing to greater radial diffusion.
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