Case Report

Multiple myeloma in a young female presenting as an aggressive skull-base tumour

Ursula Lesar, Leon Janse van Rensburg, Siobhan Oelofsen, Kevin McCree, Christelle Ackerman, Razaan Davis
South African Journal of Radiology | Vol 28, No 1 | a2883 | DOI: https://doi.org/10.4102/sajr.v28i1.2883 | © 2024 Ursula Lesar, Leon Janse van Rensburg, Siobhan Oelofsen, Kevin McCree, Christelle Ackerman, Razaan Davis | This work is licensed under CC Attribution 4.0
Submitted: 20 March 2024 | Published: 31 July 2024

About the author(s)

Ursula Lesar, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa
Leon Janse van Rensburg, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa; and Department of Radiology and Diagnostics, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa
Siobhan Oelofsen, Division of Otorhinolaryngology, Faculty of Medicine and Health Sciences, Tygerberg Hospital, Cape Town, South Africa
Kevin McCree, Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University and National Health Laboratory Service, Tygerberg Academic Hospital, Cape Town, South Africa
Christelle Ackerman, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa
Razaan Davis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg Academic Hospital, Cape Town, South Africa

Abstract

Plasma cell neoplasia has a wide presentation of disease (localised or systemic) according to the International Myeloma Working Group. Radiological imaging identifies plasmacytomas as solitary lesions or part of multiple myeloma. We present a rare case of a 21-year-old female who presented with a skull-base tumour.

Contribution: A head and neck plasmacytoma with further lytic bone lesions was confirmed on imaging. This article presents and discusses the clinical, CT, MRI, positron emission tomography (PET)-CT, histology and laboratory findings.


Keywords

multiple myeloma; plasmacytoma; young adult; atypical; head and neck; skull-base; epistaxis

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Crossref Citations

1. Multiple Myeloma in Children and Young Adults: A Systematic Literature Review
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Clinical and Experimental Medicine  vol: 26  issue: 1  year: 2026  
doi: 10.1007/s10238-026-02148-w

2. Skull-Base Plasmacytomas: A Systematic Review on Therapeutic Trends
Francisco Call-Orellana, Kishore Balasubramanian, Hanyu Qiu, Alexander Houpt, Tushar Kanti Bhadra, Georgios Toumbas, Beste Gülsuna, Jeffrey Zuccato, Panayiotis Pelargos, Abdul Basit Khan, Hakeem J. Shakir
Cancers  vol: 18  issue: 15  first page: 2495  year: 2026  
doi: 10.3390/cancers18152495