Case Report

Imaging in Van Wyk Grumbach syndrome: An uncommon presentation of hypothyroidism

Poonam Sherwani, Khanak K. Nandolia, Kirti Joshi, Radhapyari Lourembam
South African Journal of Radiology | Vol 27, No 1 | a2572 | DOI: https://doi.org/10.4102/sajr.v27i1.2572 | © 2023 Poonam Sherwani, Khanak K. Nandolia, Kirti Joshi, Radhapyari Lourembam | This work is licensed under CC Attribution 4.0
Submitted: 21 October 2022 | Published: 15 March 2023

About the author(s)

Poonam Sherwani, Department of Radiodiagnosis, All India Institute of Medical Sciences Rishikesh, Rishikesh, India
Khanak K. Nandolia, Department of Radiodiagnosis, All India Institute of Medical Sciences Rishikesh, Rishikesh, India
Kirti Joshi, Department of Paediatrics, All India Institute of Medical Sciences Rishikesh, Rishikesh, India
Radhapyari Lourembam, Department of Paediatrics, All India Institute of Medical Sciences Rishikesh, Rishikesh, India

Abstract

Isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism is well described in the literature as Van Wyk Grumbach syndrome (VWGS). The present case reports this rare entity in a 4-year-old girl who was referred for imaging to evaluate the cause of non-traumatic bleeding per vagina. Antecedent history, clinical features and thyroid function tests were consistent with long-standing juvenile hypothyroidism with documented clinical response to thyroxine replacement therapy.

Contribution: Typical clinical and radiological features of the syndrome are reported, which helps in the early diagnosis and management, henceforth avoiding the associated complications.

 


Keywords

galactorrhoea; hypothyroidism; isosexual precocious puberty; pituitary; ovarian mass; thyroid stimulating hormone (TSH); per vagina; Van Wyk Grumbach syndrome (VWGS)

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