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Case Report
Imaging in Van Wyk Grumbach syndrome: An uncommon presentation of hypothyroidism
Submitted: 21 October 2022 | Published: 15 March 2023
About the author(s)
Poonam Sherwani, Department of Radiodiagnosis, All India Institute of Medical Sciences Rishikesh, Rishikesh, IndiaKhanak K. Nandolia, Department of Radiodiagnosis, All India Institute of Medical Sciences Rishikesh, Rishikesh, India
Kirti Joshi, Department of Paediatrics, All India Institute of Medical Sciences Rishikesh, Rishikesh, India
Radhapyari Lourembam, Department of Paediatrics, All India Institute of Medical Sciences Rishikesh, Rishikesh, India
Abstract
Isosexual precocious puberty with ovarian masses in long-standing juvenile hypothyroidism is well described in the literature as Van Wyk Grumbach syndrome (VWGS). The present case reports this rare entity in a 4-year-old girl who was referred for imaging to evaluate the cause of non-traumatic bleeding per vagina. Antecedent history, clinical features and thyroid function tests were consistent with long-standing juvenile hypothyroidism with documented clinical response to thyroxine replacement therapy.
Contribution: Typical clinical and radiological features of the syndrome are reported, which helps in the early diagnosis and management, henceforth avoiding the associated complications.
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INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) vol: 21 issue: 2 first page: 160 year: 2025
doi: 10.22141/2224-0721.21.2.2025.1514