Case Report
Factor XIII deficiency in a neonate presenting as subpial haemorrhage
Submitted: 08 November 2021 | Published: 20 May 2022
About the author(s)
Monish G. Karthikeyan, Department of Radiodiagnosis, Mahatma Gandhi Medical College and Research Institute, Pondicherry, IndiaPoojitha Ronda, Department of Radiodiagnosis, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
Prabhu C. Sugumaran, Department of Radiodiagnosis, Mahatma Gandhi Medical College and Research Institute, Pondicherry, India
Abstract
Subpial haemorrhage is a rare cause of seizures in term neonates. A 3-day-old male infant, born at term with no history of perinatal hypoxia, presented with seizures and unremarkable physical examination in the interictal state. Imaging demonstrated left temporal subpial haemorrhage with the classic ‘yin-yang sign’ on MRI. The patient was subsequently diagnosed with factor XIII deficiency. Follow-up at 6 months and 12 months revealed encephalomalacia in the previous haemorrhagic areas with normal developmental milestones.
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Crossref Citations
1. Neonatal subpial hemorrhage: Padua experience and systematic review
Cristina Impieri, Claudio Ancona, Benedetta Bortolatto, Irene Laghetto, Sofia Galzignato, Margherita Nosadini, Irene Toldo, Ignazio D’Errico, Stefano Sartori, Giulia Calignano, Maria Elena Cavicchiolo, Elena Cavaliere
European Journal of Pediatrics vol: 184 issue: 4 year: 2025
doi: 10.1007/s00431-025-06021-y