Original Research

Determination of split renal function in voluntary renal donors by multidetector computed tomography and nuclear renography: How well do they correlate?

Hira Lal, Anuradha Singh, Raghunandan Prasad, Priyank Yadav, Javed Akhtar, Sukanta Barai, Prabhakar Mishra, Dharmendra Bhadauria, Anupma Kaul, Narayan Prasad, Pragati Verma
South African Journal of Radiology | Vol 25, No 1 | a2009 | DOI: https://doi.org/10.4102/sajr.v25i1.2009 | © 2021 Hira Lal, Anuradha Singh, Raghunandan Prasad, Priyank Yadav, Javed Akhtar, Sukanta Barai, Prabhakar Mishra, Dharmendra Bhadauria, Anupma Kaul, Narayan Prasad, Pragati Verma | This work is licensed under CC Attribution 4.0
Submitted: 03 October 2020 | Published: 05 March 2021

About the author(s)

Hira Lal, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Anuradha Singh, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Raghunandan Prasad, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Priyank Yadav, Department of Urology and Renal Transplantation, Faculty Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Javed Akhtar, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Sukanta Barai, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Prabhakar Mishra, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Dharmendra Bhadauria, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Anupma Kaul, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Narayan Prasad, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India
Pragati Verma, Department of Radiology, Faculty of Health Sciences, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India


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Abstract

Background: The use of computed tomography (CT) for estimation of split renal function (SRF) has been reported previously. However, most of these studies have small samples, and many do not account for the renal attenuation at CT.

Objective: The aim of this study was to compare multidetector computed tomography (MDCT) volumetry-attenuation-based SRF with that obtained via Tc99m-diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy in voluntary renal donors.

Methods: Between January 2017 and January 2020, 526 voluntary renal donors were enrolled prospectively. All donors underwent contrast CT and DTPA scan before surgery. The semiautomatic region of interest (ROI) tool was applied slice by slice on axial CT images acquired in the arterial phase. The renal contour was drawn semiautomatically with mouse clicks around the renal parenchyma, and the renal volume was ascertained. Using renal volume and attenuation, SRF was determined and compared with results obtained at DTPA imaging.

Results: The mean age was 44.91 ± 10.97 years (mean ± s.d.). There was no significant difference in SRF based on DTPA and MDCT volumetry for the left kidney (49.18% ± 3.40% vs. 49.15% ± 3.38%, p = 0.540) and for the right kidney (50.82% ± 3.40% vs. 50.86% ± 3.39%, p = 0.358). A very good correlation was observed between the two methods for the left kidney (r = 0.953, p = 0.000) and the right kidney (r = 0.955, p = 0.000). On simple linear regression analysis, 90.8% of DTPA SRF values for the left kidney and 91.3% of DTPA SRF values for the right kidney could be predicted correctly using the corresponding MDCT SRF values.

Conclusion: MDCT volumetry-attenuation-derived estimation of SRF for living renal donors could be an alternative to renal scintigraphy-based SRF estimation.


Keywords

nuclear renography; split renal function; computed tomography; volumetry; attenuation.

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