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Hypermetabolism of basal ganglia in chorea associated with antiphospholipid antibodies demonstrated by F-18 FDG

M. M. Sathekge, A. Maes, V. Thijst, M. de Roo
South African Journal of Radiology | Vol 2, No 4 | a1630 | DOI: https://doi.org/10.4102/sajr.v2i4.1630 | © 2018 M. Sathekge, A. Maes, V. Thijst, M. de Roo | This work is licensed under CC Attribution 4.0
Submitted: 15 August 2018 | Published: 30 November 1997

About the author(s)

M. M. Sathekge, Department of Nuclear Medicine, Medical University of South Africa, South Africa; and Department of Nuclear Medicine, Katholike Universiteit Leuven, Belgium
A. Maes, Department of Nuclear Medicine, Katholike Universiteit Leuven, Belgium
V. Thijst, Department of Neurology, Katholike Universiteit Leuven, Belgium
M. de Roo, Department of Nuclear Medicine, Katholike Universiteit Leuven, Belgium

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Abstract

A brain FDG PET study was performed on a 21-year-old woman with subacute chorea of unknown origin. Associated with her chorea, she had abnormal levels of antiphospholipid antibodies. She had none of the classical features of SLE nor primary antiphospholipid syndrome. The images showed high F-18 FDG uptake in the basal ganglia, while the brain MRI and EEG were normal. An association between chorea and antiphospholipid antibodies had been demonstrated before, with normal brain CT, MRI, 123IMPSPECT and cerebral angiography. The report suggests the advantage of FDG PET in imaging of unexplained cases of chorea associated with antiphospholipid antibodies.

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