Case Report

Isolated posterior fossa involvement of progressive multifocal leucoencephalopathy in HIV: A case series with review of the literature

Adziambei Mudau, Farhana E. Suleman, Clara M. Schutte, Zarina I. Lockhat
South African Journal of Radiology | Vol 21, No 2 | a1262 | DOI: https://doi.org/10.4102/sajr.v21i2.1262 | © 2017 Adziambei Mudau, Farhana E. Suleman, Clara M. Schutte, Zarina I. Lockhat | This work is licensed under CC Attribution 4.0
Submitted: 02 August 2017 | Published: 14 November 2017

About the author(s)

Adziambei Mudau, Department of Radiology, University of Pretoria, South Africa
Farhana E. Suleman, Department of Radiology, University of Pretoria, South Africa
Clara M. Schutte, Department of Neurology, University of Pretoria, South Africa
Zarina I. Lockhat, Department of Radiology, University of Pretoria, South Africa


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Abstract

Progressive multifocal leucoencephalopathy (PML) is a progressive demyelinating condition resulting from infection with the John Cunningham virus and precipitated by immunocompromised states. The HIV pandemic, especially in sub-Saharan Africa, has resulted in an increase in the number of patients presenting with PML. Imaging plays an important role in diagnosis and the distribution of the disease is predominantly supratentorial. Isolated posterior fossa involvement is a rare finding with very few cases described in the literature. We present the largest case series of patients described in the literature, with isolated posterior fossa involvement of PML, in HIV-positive patients.

Keywords

HIV; PML; MRI

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