Case Report

Advanced tumour-induced osteomalacia secondary to sinonasal phosphaturic mesenchymal tumour

Monica van Wijk, Leon Janse van Rensburg, Bianca D. Berndorfler, Johan F. Opperman, Johan Grobbelaar, Amir H. Afrogheh, Sarah Versveld, Razaan Davis
South African Journal of Radiology | Vol 28, No 1 | a2975 | DOI: https://doi.org/10.4102/sajr.v28i1.2975 | © 2024 Monica van Wijk, Leon Janse van Rensburg, Bianca D. Berndorfler, Johan F. Opperman, Johan Grobbelaar, Amir H. Afrogheh, Sarah Versveld, Razaan Davis | This work is licensed under Other
Submitted: 30 June 2024 | Published: 22 October 2024

About the author(s)

Monica van Wijk, Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa
Leon Janse van Rensburg, Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa
Bianca D. Berndorfler, Nuclear Medicine Division, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa
Johan F. Opperman, Department of Oral and Maxillofacial Pathology, National Health Laboratory Service and University of the Western Cape, Cape Town, South Africa; and Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Johan Grobbelaar, Division of Otorhinolaryngology, Department of Surgery, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa
Amir H. Afrogheh, Department of Oral and Maxillofacial Pathology, National Health Laboratory Service and University of the Western Cape, Cape Town, South Africa; and Division of Anatomical Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Sarah Versveld, Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa
Razaan Davis, Division of Radiodiagnosis, Department of Medical Imaging and Clinical Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa

Abstract

Phosphaturic mesenchymal tumours (PMT) are rare, benign lesions and the most common tumour to cause tumour-induced osteomalacia (TIO), a paraneoplastic syndrome. Patients frequently exhibit severe osteomalacia, accompanied by multiple fractures, which significantly impair their quality of life. Complete surgical resection is curative.

Contribution: A rare case of sinonasal PMT is presented, with a focus on the imaging findings and role of the radiologist and nuclear physician.


Keywords

phosphaturic; mesenchymal; tumour; induced; osteomalacia; TIO; fractures; sinosanal; radiology; nuclear

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Crossref Citations

1. Pediatric and Adult Sinonasal Phosphaturic Mesenchymal Tumors: CDKN2A Copy Number Alterations and Their Association with Recurrence
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doi: 10.1007/s12105-026-01970-8