Case Report

Anti-Ma2-antibody-associated encephalitis: An atypical paraneoplastic neurologic syndrome

Bogna Targonska, Jamie Frost, Sanjay Prabhu
South African Journal of Radiology | Vol 22, No 1 | a1310 | DOI: | © 2018 Bogna Targonska, Jamie Frost, Sanjay Prabhu | This work is licensed under CC Attribution 4.0
Submitted: 15 January 2018 | Published: 17 May 2018

About the author(s)

Bogna Targonska, Department of Radiology, Renown Regional Medical Center, Reno, NV, United States
Jamie Frost, Helen DeVos Childrens Hospital, Advanced Radiology Services, Grand Rapids, MI, United States
Sanjay Prabhu, Department of Radiology, Boston Children’s Hospital, Boston, MA, United States


Paraneoplastic syndromes are a heterogeneous group of conditions affecting cancer patients, where the signs and symptoms are not owing to the local effects of the tumour but instead owing to humoral or immunologic effects. We describe an unusual presentation of a paraneoplastic neurologic syndrome presenting with predominant involvement of the hypothalamus and deep grey nuclei secondary to an anterior mediastinal germinoma and associated with anti-Ma2 antibody.


Paraneoplastic; encephalitis


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Crossref Citations

1. Anti-Ma2 Encephalitis: An Atypical Case Associated With Klüver-Bucy Syndrome and Hypothalamic Dysfunction
Cort Wernz, Lauren Pupa, Ashley Ossimetha, Sahifah Ansari, Fanny Moron
Cureus  year: 2023  
doi: 10.7759/cureus.40816